@article{pmid36001293,

title = {Novel chemically cross-linked self-molding particulate sorbents as solid-phase extraction media},

author = {Yuta Miki and Hiroya Murakami and Marin Gotoh and Tomonari Umemura and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},

doi = {10.1007/s44211-022-00179-3},

issn = {1348-2246},

year  = {2023},

date = {2023-05-01},

journal = {Anal Sci},

volume = {39},

number = {5},

pages = {749--754},

abstract = {Here, we describe novel, chemically cross-linked, self-molding particulate polymer sorbents that are utilized as a molding-type solid-phase extraction medium (M-SPEM), which exhibits high permeability and rigidness. To fabricate such M-SPEM, first, polyethyleneimine (PEI)-modified reversed-phase (RP)-type particulate sorbents were synthesized, thereafter, they were chemically cross-linked by a polymer having many epoxy groups together with additional PEI. By optimizing the binding conditions of the particulate sorbents, the resultant M-SPEM has almost the same adsorption properties as the corresponding unmolded particulate sorbent for some polar (e.g., uracil and adenine) compounds. The binding technique proposed here is expected to facilitate the fabrication of molding-type sorbents and improve the performance of the SPE procedure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36577893,

title = {Hydrophilic interaction chromatography-type sorbent prepared by the modification of methacrylate-base resin with polyethyleneimine for solid-phase extraction of polar compounds},

author = {Hiroya Murakami and Keisuke Iida and Yuki Oda and Tomonari Umemura and Hizuru Nakajima and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},

doi = {10.1007/s44211-022-00250-z},

issn = {1348-2246},

year  = {2023},

date = {2023-03-01},

journal = {Anal Sci},

volume = {39},

number = {3},

pages = {375--381},

abstract = {Hydrophilic interaction chromatography (HILIC)-type sorbents were newly developed for the solid-phase extraction (SPE) of polar compounds. Two methacrylate-base resins with different cross-linking monomers and pore properties were synthesized, and three polyethyleneimines (PEIs) with different molecular weights were modified onto each base resin. In both cases, PEIs with a molecular weight of 10,000 (PEI-10,000) exhibited the highest adsorption properties for polar compounds (uracil, uridine, adenosine, cytidine, and guanosine). To control the water-enriched layer at the surface of the PEI-10,000-modified sorbents, the additive amount of PEI-10,000 in the modified reaction was also optimized. When 10 times the amount of PEI-10,000 to each base resin was added, an improvement in adsorption property was observed. Moreover, the use of a nonaqueous sample solution (100% acetonitrile) during the sample loading process drastically improved adsorption, especially for uracil (about 80%) and adenosine (100%). These results indicate that the formation of a strong water-enriched layer at the surface of sorbents with an effective expression of hydrophilic interaction was an important factor in the adsorption properties of polar compounds in HILIC mode-SPE.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34996015,

title = {Development of a surface plasmon resonance sensor using an optical fiber prepared by electroless displacement gold plating and its application to immunoassay},

author = {Atsushi Shoji and Miyu Nakajima and Kazuhiro Morioka and Eiji Fujimori and Tomonari Umemura and Akio Yanagida and Akihide Hemmi and Katsumi Uchiyama and Hizuru Nakajima},

doi = {10.1016/j.talanta.2021.123162},

issn = {1873-3573},

year  = {2022},

date = {2022-04-01},

journal = {Talanta},

volume = {240},

pages = {123162},

abstract = {A simple and low-cost method of fabricating an optical fiber for a surface plasmon resonance (SPR) sensor was proposed. The method is based on the electroless nickel plating and subsequent displacement gold plating of the core of the optical fiber. The thickness of the nickel and gold thin films deposited on the core of the optical fiber could be controlled by measuring the reflected light intensity from the tip of the optical fiber during the plating processes. The sensitivity and resolution of the SPR sensor with the fabricated optical fiber in the refractive index range from 1.333 to 1.348 were 1324.3 nm/RIU and 7.6 × 10 RIU, respectively. The developed SPR sensor was successfully used in the determination of immunoglobulin A (IgA) in human saliva. The IgA quantification results obtained by the SPR sensor were in excellent agreement with those obtained by conventional enzyme-linked immunosorbent assay using a 96-well microtiter plate.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35314976,

title = {Preparation and evaluation of molding-type solid-phase extraction media binding with commercially available adhesives},

author = {Yuta Miki and Hiroya Murakami and Keisuke Iida and Tomonari Umemura and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},

doi = {10.2116/analsci.21P265},

issn = {1348-2246},

year  = {2022},

date = {2022-02-01},

journal = {Anal Sci},

volume = {38},

number = {2},

pages = {307--315},

abstract = {A fabrication method of molding-type solid-phase extraction media (M-SPEM) bound with commercially available adhesive is presented. Six pieces of M-SPEM were prepared by heating each kneaded product of a particulate sorbent and an adhesive inserted into a six-hole cylindrical mold for hardening under an open system and normal pressure. The particulate sorbent contained in M-SPEM was divinylbenzene-based reversed-phase mode solid-phase extractants that we have reported. An examination of several adhesives showed that the moldability of M-SPEM depended on the composition and properties of the adhesive. The optimized procedure can be used to prepare an M-SPEM containing an 85 wt% particulate sorbent (particulate sorbent/adhesive, 100 mg/17 mg; particle diameter, 90-150 µm), and the M-SPEM has a specific surface area of about 500 m/g. The established procedure in this study can bind particulate sorbents together, which showed almost no reductions in the adsorption property and liquid permeability compared with those of the particulate sorbent.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{article,

title = {Development of Portable Fluorescence Microplate Reader Equipped with Indium Tin Oxide Glass Heater for Loop-mediated Isothermal Amplification},

author = {Ryo Ishii and Kazuhiro Morioka and Takuya Mizumoto and Natsumi Yamasaki and Akihide Hemmi and Atsushi Shoji and Hiroya Murakami and Norio Teshima and Tomonari Umemura and Katsumi Uchiyama and Hizuru Nakajima},

doi = {10.18494/SAM.2022.3618},

year  = {2022},

date = {2022-01-01},

journal = {Sensors and Materials},

volume = {34},

pages = {1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{MIYAUCHI2021102394,

title = {Development of an algal cell-attached solid surface culture system for simultaneous wastewater treatment and biomass production},

author = {Hiroki Miyauchi and Kohei Harada and Yoshino Suzuki and Katsuhiko Okada and Motohide Aoki and Tomonari Umemura and Shoko Fujiwara and Mikio Tsuzuki},

url = {https://www.sciencedirect.com/science/article/pii/S2211926421002137},

doi = {https://doi.org/10.1016/j.algal.2021.102394},

issn = {2211-9264},

year  = {2021},

date = {2021-07-06},

journal = {Algal Research},

volume = {58},

pages = {102394},

abstract = {Wastewater treatment using microalgae is receiving growing attention. Here, we have developed a portable tubular system containing an algal cell-coated solid surface for phosphorous recovery. P-depleted Chlorella cells attached to a solid surface removed phosphate from the medium about 70 times faster than P-replete cells. When the cell density was 20 g dry cell weight m−2 or less, P-depleted cells on the solid surface absorbed phosphate from the medium at almost the same rate as in liquid, the maximum capacity per solid surface area being about 6 mg P m−2 min−1. P in inorganic wastewater from chemical factories (ethanol factories; about 4 mg L−1) and in pond water (0.06 mg L−1) was mostly removed within 3 h with a simple device composed of a single solid-surfaced sheet (0.002 m−2) and a portable compact tubular device including 12 such sheets (totally 0.5 m−2), respectively. Simultaneously, cellular growth was confirmed with both wastewater and pond water. These findings suggested that the attached cell culture system, in which medium exchange to prepare P-depleted cells is much easier than in liquid cultures, is promising for dual use for biomass production and wastewater treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{articlec,

title = {Development of a fluorescence microplate reader using an organic photodiode array with a large light receiving area},

author = {Kazuhiro Morioka and Moeko Osashima and Nao Azuma and Kuizhi Qu and Akihide Hemmi and Atsushi Shoji and Hiroya Murakami and Norio Teshima and Tomonari Umemura and Katsumi Uchiyama and Hizuru Nakajima},

doi = {10.1016/j.talanta.2021.122994},

year  = {2021},

date = {2021-01-01},

journal = {Talanta},

volume = {238},

pages = {122994},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{articled,

title = {Preparation and Evaluation of Molding-type Solid-phase Extraction Media Binding with Commercially Available Adhesives},

author = {Yuta MIKI and Hiroya MURAKAMI and Keisuke IIDA and Tomonari UMEMURA and Yukihiro ESAKA and Yoshinori INOUE and Norio TESHIMA},

doi = {10.2116/analsci.21P265},

year  = {2021},

date = {2021-01-01},

journal = {Analytical Sciences},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Matsuo12.02.2020,

title = {Chemical Constituents of the Terrestrial Stems of Ephedra sinica and their PPAR-γ Ligand-Binding Activity},

author = {Yukiko Matsuo and Mayu Sasaki and Haruhiko Fukaya and Katsunori Miyake and Riko Takeuchi and Hidetoshi Kumata and Yoshihiro Mimaki},

url = {https://doi.org/10.1055/a-1094-9229},

doi = {10.1055/a-1094-9229},

issn = {2509-9264},

year  = {2020},

date = {2020-02-20},

journal = {Planta Medica International Open},

volume = {7},

number = {01},

pages = {e12-e16},

note = {e12},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{KISHI2020113253,

title = {HPLC with electrochemical detection for determining homogentisic acid and its application to urine from rats fed tyrosine-enriched food},

author = {Takuho Kishi and Akira Kotani and Tomonari Umemura and Hideki Hakamata},

url = {http://www.sciencedirect.com/science/article/pii/S073170851932967X},

doi = {https://doi.org/10.1016/j.jpba.2020.113253},

issn = {0731-7085},

year  = {2020},

date = {2020-01-01},

journal = {Journal of Pharmaceutical and Biomedical Analysis},

volume = {186},

pages = {113253},

abstract = {A highly sensitive method for determining urine homogentisic acid (HGA) is required to provide adequate diagnosis and therapy for alkaptonuria in early stages. In this study, we developed a highly sensitive high-performance liquid chromatography with electrochemical detection (HPLC-ECD) for determining HGA in urine. In order to obtain a chromatogram of HGA by HPLC-ECD, an oxidation current was monitored at +0.5 V vs. Ag/AgCl. The peak heights of HGA showed linearity (r = 0.999) ranging from 4.2 ng/mL to 168 ng/mL, and the detection limit was 1.2 ng/mL (signal-to-noise ratio, S/N = 3). In recovery tests using human control urine spiked with an HGA standard, the recoveries of HGA were more than 93.2 %, and the relative standard deviations (n = 6) were less than 1.9 %. As an in vivo application using male Wistar rats, the level of urine HGA, which was metabolized from tyrosine in tyrosine-enriched food, was determined by this HPLC-ECD method. The determination of HGA in urine by this HPLC-ECD method requires only 0.1 mL of a rat urine specimen and simple sample preparation consisting of dilution and filtration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ENDO2020113448,

title = {Reduced bioavailability of polycyclic aromatic hydrocarbons (PAHs) in sediments impacted by carbon manufacturing plant effluent: Evaluation by ex situ passive sampling method},

author = {Satoshi Endo and Mitsuki Yoshimura and Hidetoshi Kumata and Masao Uchida and Yoshinori Yabuki and Haruhiko Nakata},

url = {http://www.sciencedirect.com/science/article/pii/S0269749119349796},

doi = {https://doi.org/10.1016/j.envpol.2019.113448},

issn = {0269-7491},

year  = {2020},

date = {2020-01-01},

journal = {Environmental Pollution},

volume = {256},

pages = {113448},

abstract = {Potential risks of polycyclic aromatic hydrocarbons (PAHs) in sediments of a Japanese bay contaminated by carbon manufacturing plant effluent were evaluated by calculating toxicity units (TUs). TUs calculated from the measured whole-sediment concentrations (Cwhole) were often higher than or close to 1, signaling a possible toxicity concern to benthic organisms. In contrast, TUs based on the freely dissolved pore water concentrations (Cfree) measured by an ex-situ passive sampling method with polyethylene strips were 0.0007–0.005, much lower than 1, indicating no effect. We also found that the fractions of black carbon in sediments of the contaminated bay were significantly higher than those of reference sites. Overall, we conclude that carbon manufacturing plant effluent substantially increases Cwhole of PAHs in sediments but also increases the fraction of carbonaceous particles that strongly retain PAHs. As a combined result, bioavailable concentrations (as expressed by pore water Cfree) of PAHs do not increase as much as Cwhole. The results of this study indicate that ecotoxicological risks of PAH contamination by carbon manufacturing plants should be evaluated by directly measuring pore water Cfree instead of Cwhole.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{曲奎智2020,

title = {自律送液が可能なマイクロチップと有機フォトダイオード検出器を用いる化学発光分析システムの開発},

author = {曲,奎智 and 森岡,和大 and 東,奈穗 and 長嶋,萌子 and 辺見,彰秀 and 東海林,敦 and 村上,博哉 and 手嶋,紀雄 and 梅村,知也 and 加藤,俊吾 and 河西,奈保子 and 内山,一美 and 中嶋,秀},

doi = {10.2116/bunsekikagaku.69.31},

year  = {2020},

date = {2020-01-01},

journal = {分析化学},

volume = {69},

number = {1.2},

pages = {31-39},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{MURAKAMI2020121052,

title = {Evaluation of the adsorption properties of nucleobase-modified sorbents for a solid-phase extraction of water-soluble compounds},

author = {Hiroya Murakami and Miho Omiya and Yuta Miki and Tomonari Umemura and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},

url = {http://www.sciencedirect.com/science/article/pii/S003991402030343X},

doi = {https://doi.org/10.1016/j.talanta.2020.121052},

issn = {0039-9140},

year  = {2020},

date = {2020-01-01},

journal = {Talanta},

volume = {217},

pages = {121052},

abstract = {We developed hydrophilic interaction chromatography (HILIC)-type sorbents modified with nucleobases for solid phase extraction (SPE). The synthesized hydrophilic base resins were modified by each nucleobase (adenine, guanine, and cytosine). The measurement of the amount of water content indicated that each nucleobase-modified sorbent had a water layer. To evaluate the adsorption properties in the HILIC mode, we chose two nucleobases (uracil and adenine) and four nucleosides (uridine, adenosine, cytidine, guanosine) as water-soluble analytes, which were loaded into an SPE cartridge packed with the nucleobase-modified sorbent. Firstly, 95% acetonitrile (ACN) solutions were used in the process of conditioning and sample loading of the above polar analytes. High recoveries of the analytes were observed in each nucleobase-modified sorbent, and the Diol-type sorbent (no modification with any of the nucleobases) did not adsorb each water-soluble analyte. On the basis of this result, a 98% ACN solution was used during the process of conditioning and sample loading to decrease the concentration of water in the sample, which potentially inhibited the formation of hydrogen bonding between each analyte and the modified nucleobase. Considerable improvements of recoveries were observed in Adenine- and Cytosine-modified sorbents. These results were possibly attributed to the effective expression of hydrogen bonding by decreasing water concentration in the sample solution. Although a non-aqueous (100% ACN) sample solution can be expected to obtain higher recoveries compared with the 98% ACN solution, a decrease in recoveries was observed in Adenine-modified sorbent. From these results, the highest adsorption property was observed in Adenine-modified sorbent using 98% ACN as a sample condition, and the combination of this sample condition and sorbent is effective for high adsorption under HILIC condition. Moreover, we also revealed that a balance between the thickness of water layer and the modification amount of nucleobase is important for retention in the HILIC-type sorbent.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{KUMATA2020100009,

title = {Elimination of interfering molybdenum oxyanion with an anion-exchange monolithic spin tip (AXTip) for precise determination of cadmium in human urine by ICP-MS},

author = {Hidetoshi Kumata and Chika Morimoto and Akihiro Horie and Akane Tanabe and Eiji Fujimori and Tomonari Umemura},

url = {http://www.sciencedirect.com/science/article/pii/S2666831920300096},

doi = {https://doi.org/10.1016/j.talo.2020.100009},

issn = {2666-8319},

year  = {2020},

date = {2020-01-01},

journal = {Talanta Open},

pages = {100009},

abstract = {A simple purification technique using an anion-exchange monolithic spin tip was described for the elimination of molybdenum oxyanion interfering with precise determination of cadmium in human urine samples by ICP-MS. The tip device named “anion-exchange tip-in monolith (AXTip)” was laboratory-prepared within the confines of a commercially available syringe filter tip by a two-step process: (1) in situ copolymerization of glycidyl methacrylate (GMA) and ethylene dimethacrylate (EDMA) and (2) its subsequent modification with trimethylamine (TMA), as a strong anion-exchange functional group, via ring-opening reaction of epoxide. The adsorption capacity of the AXTip was >3.2 μmol/tip for molybdenum oxyanion. The performance of the AXTip was evaluated through an adsorption/non-adsorption experiment for molybdenum, cadmium and other metal and metalloid species, using a model solution and human urine samples to optimize the sample solution's pH and dilution factor for the AXTip treatment. In the case of urine sample analysis, 8 times dilution and pH adjustment to 4.0 prior to AXTip treatment were found to allow >98 % elimination of interfering molybdenum oxyanions and quantitative recovery (103±7 %) of cadmium. At the optimized conditions, the AXTip treatment reduces Mo/Cd ratio from ∼400 in human urines to <10, which is sufficient for conducting ICP-MS measurement of cadmium in no-gas mode (without collision/reaction cell technique). The proposed purification technique was validated through the analysis of an accuracy control material of human urine (Seronorm™ Trace Elements Urine L-1). Good agreement of the observed values with the reference values indicates that the proposed technique is practically applicable.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{今崎龍之介2020,

title = {超薄層クロマトグラフィー用の水平式ミニチュアTLC展開槽の試作と評価},

author = {今崎,龍之介 and 近藤,啓太 and 谷,夏海 and 青木,元秀 and 熊田,英峰 and 内田,達也 and 長縄,豪 and 嶋田,泰佑 and 田口,嘉彦 and 佐藤,浩明 and 安井,隆雄 and 梅村,知也},

doi = {10.2116/bunsekikagaku.69.553},

year  = {2020},

date = {2020-01-01},

journal = {分析化学},

volume = {69},

number = {10.11},

pages = {553-558},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{articlef,

title = {The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites},

author = {Yuichi Wakana and Kaito Hayashi and Takumi Nemoto and Chiaki Watanabe and Masato Taoka and Jessica Angulo-Capel and Maria Parajo and Hidetoshi Kumata and Tomonari Umemura and Hiroki Inoue and Kohei Arasaki and Felix Campelo and Mitsuo Tagaya},

doi = {10.1083/jcb.202002150},

year  = {2020},

date = {2020-01-01},

journal = {Journal of Cell Biology},

volume = {220},

keywords = {},

pubstate = {published},

tppubtype = {article}

}