Welcome to our laboratory’s website!!!

The mission of our laboratory is to develop new analytical methods that can measure and/or observe directly interactions between chemical substances and living cells/organisms, and to understand molecular, cellular, individual and ecosystem-level mechanism that life respond to the chemical environmental changes. Our long-term goal is to use the knowledge gained from our research to contribute to solution of drug design or an environmental problem.

2018 Member

Recent Pubrications


Ishii, Ryo; Morioka, Kazuhiro; Mizumoto, Takuya; Yamasaki, Natsumi; Hemmi, Akihide; Shoji, Atsushi; Murakami, Hiroya; Teshima, Norio; Umemura, Tomonari; Uchiyama, Katsumi; Nakajima, Hizuru

Development of Portable Fluorescence Microplate Reader Equipped with Indium Tin Oxide Glass Heater for Loop-mediated Isothermal Amplification Journal Article

In: Sensors and Materials, vol. 34, pp. 1, 2022.

Links | BibTeX


Miyauchi, Hiroki; Harada, Kohei; Suzuki, Yoshino; Okada, Katsuhiko; Aoki, Motohide; Umemura, Tomonari; Fujiwara, Shoko; Tsuzuki, Mikio

Development of an algal cell-attached solid surface culture system for simultaneous wastewater treatment and biomass production Journal Article

In: Algal Research, vol. 58, pp. 102394, 2021, ISSN: 2211-9264.

Abstract | Links | BibTeX

Shoji, Atsushi; Nakajima, Miyu; Morioka, Kazuhiro; Fujimori, Eiji; Umemura, Tomonari; Yanagida, Akio; Hemmi, Akihide; Uchiyama, Katsumi; Nakajima, Hizuru

Development of a surface plasmon resonance sensor using an optical fiber prepared by electroless displacement gold plating and its application to immunoassay Journal Article

In: Talanta, vol. 240, pp. 123162, 2021.

Links | BibTeX

Morioka, Kazuhiro; Osashima, Moeko; Azuma, Nao; Qu, Kuizhi; Hemmi, Akihide; Shoji, Atsushi; Murakami, Hiroya; Teshima, Norio; Umemura, Tomonari; Uchiyama, Katsumi; Nakajima, Hizuru

Development of a fluorescence microplate reader using an organic photodiode array with a large light receiving area Journal Article

In: Talanta, vol. 238, pp. 122994, 2021.

Links | BibTeX

MIKI, Yuta; MURAKAMI, Hiroya; IIDA, Keisuke; UMEMURA, Tomonari; ESAKA, Yukihiro; INOUE, Yoshinori; TESHIMA, Norio

Preparation and Evaluation of Molding-type Solid-phase Extraction Media Binding with Commercially Available Adhesives Journal Article

In: Analytical Sciences, 2021.

Links | BibTeX


Matsuo, Yukiko; Sasaki, Mayu; Fukaya, Haruhiko; Miyake, Katsunori; Takeuchi, Riko; Kumata, Hidetoshi; Mimaki, Yoshihiro

Chemical Constituents of the Terrestrial Stems of Ephedra sinica and their PPAR-γ Ligand-Binding Activity Journal Article

In: Planta Medica International Open, vol. 7, no. 01, pp. e12-e16, 2020, ISSN: 2509-9264, (e12).

Links | BibTeX

Kishi, Takuho; Kotani, Akira; Umemura, Tomonari; Hakamata, Hideki

HPLC with electrochemical detection for determining homogentisic acid and its application to urine from rats fed tyrosine-enriched food Journal Article

In: Journal of Pharmaceutical and Biomedical Analysis, vol. 186, pp. 113253, 2020, ISSN: 0731-7085.

Abstract | Links | BibTeX

Endo, Satoshi; Yoshimura, Mitsuki; Kumata, Hidetoshi; Uchida, Masao; Yabuki, Yoshinori; Nakata, Haruhiko

Reduced bioavailability of polycyclic aromatic hydrocarbons (PAHs) in sediments impacted by carbon manufacturing plant effluent: Evaluation by ex situ passive sampling method Journal Article

In: Environmental Pollution, vol. 256, pp. 113448, 2020, ISSN: 0269-7491.

Abstract | Links | BibTeX

曲, 奎智; 森岡, 和大; 東, 奈穗; 長嶋, 萌子; 辺見, 彰秀; 東海林, 敦; 村上, 博哉; 手嶋, 紀雄; 梅村, 知也; 加藤, 俊吾; 河西, 奈保子; 内山, 一美; 中嶋, 秀

自律送液が可能なマイクロチップと有機フォトダイオード検出器を用いる化学発光分析システムの開発 Journal Article

In: 分析化学, vol. 69, no. 1.2, pp. 31-39, 2020.

Links | BibTeX

Murakami, Hiroya; Omiya, Miho; Miki, Yuta; Umemura, Tomonari; Esaka, Yukihiro; Inoue, Yoshinori; Teshima, Norio

Evaluation of the adsorption properties of nucleobase-modified sorbents for a solid-phase extraction of water-soluble compounds Journal Article

In: Talanta, vol. 217, pp. 121052, 2020, ISSN: 0039-9140.

Abstract | Links | BibTeX

Kumata, Hidetoshi; Morimoto, Chika; Horie, Akihiro; Tanabe, Akane; Fujimori, Eiji; Umemura, Tomonari

Elimination of interfering molybdenum oxyanion with an anion-exchange monolithic spin tip (AXTip) for precise determination of cadmium in human urine by ICP-MS Journal Article

In: Talanta Open, pp. 100009, 2020, ISSN: 2666-8319.

Abstract | Links | BibTeX

今崎, 龍之介; 近藤, 啓太; 谷, 夏海; 青木, 元秀; 熊田, 英峰; 内田, 達也; 長縄, 豪; 嶋田, 泰佑; 田口, 嘉彦; 佐藤, 浩明; 安井, 隆雄; 梅村, 知也

超薄層クロマトグラフィー用の水平式ミニチュアTLC展開槽の試作と評価 Journal Article

In: 分析化学, vol. 69, no. 10.11, pp. 553-558, 2020.

Links | BibTeX

Wakana, Yuichi; Hayashi, Kaito; Nemoto, Takumi; Watanabe, Chiaki; Taoka, Masato; Angulo-Capel, Jessica; Parajo, Maria; Kumata, Hidetoshi; Umemura, Tomonari; Inoue, Hiroki; Arasaki, Kohei; Campelo, Felix; Tagaya, Mitsuo

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites Journal Article

In: Journal of Cell Biology, vol. 220, 2020.

Links | BibTeX


Tani, Hidenori; Numajiri, Ayaka; Aoki, Motohide; Umemura, Tomonari; Nakazato, Tetsuya

Short-lived long noncoding RNAs as surrogate indicators for chemical stress in HepG2 cells and their degradation by nuclear RNases Journal Article

In: Scientific Reports, vol. 9, pp. 20299, 2019, ISSN: 2045-2322.

Abstract | Links | BibTeX

Umemura, Tomonari

Elucidation of Ion-Pairing Elution Behavior of Anions and Cations in Electrostatic Ion Chromatography Using Water as a Mobile Phase Journal Article

In: Chromatography, vol. 40, pp. 143-148, 2019, ISSN: 1342-8284.


竹内, 理子; 力石, 嘉人; 小川, 奈々子; 風呂田, 郷史; 大河内, 直彦; 青木, 元秀; 内田, 達也; 梅村, 知也; 熊田, 英峰

化合物レベル炭素安定同位体比分析のための高等植物中のステロール及び脂肪酸の分離精製法の確立 Journal Article

In: 分析化学, vol. 68, no. 5, pp. 297-306, 2019.

Links | BibTeX

Murota, Chisato; Fujiwara, Shoko; Tsujishita, Maki; Urabe, Kanae; Takayanagi, Shuta; Aoki, Motohide; Umemura, Tomonari; Eaton-Rye, Julian J; Pitt, Frances D; Tsuzuki, Mikio

Hyper-resistance to arsenate in the cyanobacterium Synechocystis sp. PCC 6803 is influenced by the differential kinetics of its pst-ABC transporters and external phosphate concentration exposure Journal Article

In: Algal Research, vol. 38, pp. 101410, 2019, ISSN: 2211-9264.

Abstract | Links | BibTeX

Nagashima, Shun; Takeda, Keisuke; Ohno, Nobuhiko; Ishido, Satoshi; Aoki, Motohide; Saitoh, Yurika; Takada, Takumi; Tokuyama, Takeshi; Sugiura, Ayumu; Fukuda, Toshifumi; Matsushita, Nobuko; Inatome, Ryoko; Yanagi, Shigeru

MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress Journal Article

In: Life Science Alliance, vol. 2, no. 4, 2019.

Abstract | Links | BibTeX