{"id":79,"date":"2021-07-15T15:02:43","date_gmt":"2021-07-15T06:02:43","guid":{"rendered":"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/?page_id=79"},"modified":"2021-09-22T15:36:35","modified_gmt":"2021-09-22T06:36:35","slug":"research","status":"publish","type":"page","link":"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/?page_id=79","title":{"rendered":"\u7814\u7a76"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u3088\u3046\u3053\u305d\u7d30\u80de\u60c5\u5831\u79d1\u5b66\u7814\u7a76\u5ba4\u3078<\/h2>\n\n\n\n<p class=\"has-vivid-purple-color has-text-color has-large-font-size\">Welcome!<\/p>\n\n\n\n<p>\u3053\u3093\u306b\u3061\u306f\u3002\u79c1\u305f\u3061\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3092\u8a2a\u308c\u3066\u3044\u305f\u3060\u304d\u6709\u96e3\u3046\u3054\u3056\u3044\u307e\u3059\u3002<br><br>\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u751f\u5316\u5b66\u7684\u3001\u7d30\u80de\u751f\u7269\u5b66\u7684\u3001\u907a\u4f1d\u5b66\u7684\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u7ffb\u8a33\u5f8c\u4fee\u98fe\u95a2\u9023\u9175\u7d20\u3001\u304c\u3093\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<br><br>\u5927\u5b66\u9662\u751f\u3068\u5b66\u90e8\uff14\u5e74\u751f\u3092\u4f75\u305b\u3066\u3001\uff115\u4eba\u7a0b\u5ea6\u306e\u30a2\u30c3\u30c8\u30db\u30fc\u30e0\u306a\u7814\u7a76\u5ba4\u3067\u3059\u3002<br><br>\u7d30\u80de\u60c5\u5831\u79d1\u5b66\u7814\u7a76\u5ba4\u3067\u306f\u3001\u4e00\u7dd2\u306b\u7814\u7a76\u3057\u3066\u304f\u308c\u308b\u5b66\u90e8\u751f\u3001\u5927\u5b66\u9662\u751f\u3092\u52df\u96c6\u3057\u3066\u3044\u307e \u3059\u3002\u662f\u975e\u4e00\u5ea6\u3001\u898b\u5b66\u306b\u6765\u3066\u304f\u3060\u3055\u3044\u3002\u8cea\u554f\u306e\u3042\u308b\u65b9\u306f\u3001\u3069\u3093\u306a\u8cea\u554f\u3067\u3082\u7d50\u69cb\u3067\u3059\u306e\u3067\u3001 \u6c17\u8efd\u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002\u7686\u3055\u3093\u3068\u4e00\u7dd2\u306b\u7814\u7a76\u3067\u304d\u308b\u3053\u3068\u3092\u5fc3\u5f85\u3061\u306b\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u5ba4\u306e\u8a2d\u5099\u306f\u3053\u3061\u3089\u304b\u3089\u3054\u89a7\u3044\u305f\u3060\u3051\u307e\u3059\u3002<span style=\"background-color: #ffff00;\"><strong><a style=\"background-color: #ffff00;\" href=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/?page_id=556\">\u7814\u7a76\u5ba4\u30c4\u30a2\u30fc<\/a><\/strong><\/span><br \/><br \/>\u4f0a\u85e4\u3000\u662d\u535a \u554f\u3044\u5408\u308f\u305b\u306f\u3053\u3061\u3089\u304b\u3089\u2193<br \/>aito(a)toyaku.ac.jp<\/p>\n\n\n\n<figure class=\"wp-block-gallery columns-2 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\"><ul class=\"blocks-gallery-grid\"><li class=\"blocks-gallery-item\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"370\" height=\"289\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0096.jpg\" alt=\"\" data-id=\"80\" data-link=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/?attachment_id=80\" class=\"wp-image-80\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0096.jpg 370w, https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0096-300x234.jpg 300w\" sizes=\"auto, (max-width: 370px) 100vw, 370px\" \/><\/figure><\/li><li class=\"blocks-gallery-item\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"370\" height=\"289\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0097.jpg\" alt=\"\" data-id=\"81\" data-full-url=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0097.jpg\" data-link=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/?attachment_id=81\" class=\"wp-image-81\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0097.jpg 370w, https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/IMG_0097-300x234.jpg 300w\" sizes=\"auto, (max-width: 370px) 100vw, 370px\" \/><\/figure><\/li><\/ul><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#a01\" data-type=\"internal\" data-id=\"#a01\">01.\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30b8\u30f3\u30a2\u30bb\u30c1\u30eb\u5316\/\u30a2\u30b7\u30eb\u5316\u4fee\u98fe\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/h3>\n\n\n\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u306f\u30b2\u30ce\u30e0DNA\u4e2d\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u30a2\u30df\u30ce\u9178\u914d\u5217\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u304c\u3001\u591a\u304f\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7ffb\u8a33\u6642\u3042\u308b\u3044\u306f\u7ffb\u8a33\u5f8c\u306b\u69d8\u3005\u306a\u4fee\u98fe\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u304c\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306b\u306f\u69d8\u3005\u306a\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30ea\u30b8\u30f3\u6b8b\u57fa\u306f\u30e6\u30d3\u30ad\u30c1\u30f3\u3001SUMO (small ubiquitin-like modifier) \u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u4fee\u98fe\u306b\u52a0\u3048\u3066\u3001\u30a2\u30bb\u30c1\u30eb\u57fa\u3001\u30e1\u30c1\u30eb\u57fa\u306a\u3069\u306e\u5316\u5b66\u57fa\u306b\u3088\u308b\u4fee\u98fe\u306a\u3069\u3001\u975e\u5e38\u306b\u591a\u69d8\u306a\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u4fee\u98fe\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b89\u5b9a\u5316\u3001\u5c40\u5728\u3001\u6d3b\u6027\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u306a\u3069\u3092\u5909\u5316\u3055\u305b\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u305f\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u306b\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30ea\u30b8\u30f3\u6b8b\u57fa\u4e0a\u3067\u8d77\u3053\u308b\u591a\u69d8\u306a\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\u4e2d\u3067\u3082\u30a2\u30bb\u30c1\u30eb\u5316\u304a\u3088\u3073\u3001\u6700\u8fd1\u898b\u3064\u304b\u3063\u305f\u9577\u9396\u30a2\u30b7\u30eb\u5316\u4fee\u98fe\u306b\u7279\u306b\u6ce8\u76ee\u3057\u3001\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#a02\" data-type=\"internal\" data-id=\"#a02\">02.NAD+\u4f9d\u5b58\u7684\u30ea\u30b8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a><\/h3>\n\n\n\n<p>\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306f\u5927\u8178\u83cc\u304b\u3089\u30d2\u30c8\u307e\u3067\u7a2e\u3092\u8d85\u3048\u3066\u4fdd\u5b58\u3055\u308c\u3001NAD+\u4f9d\u5b58\u7684\u30ea\u30b8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u6d3b\u6027\u3092\u6709\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u30d2\u30c8\u3067\u306f7\u7a2e\u985e\u306e\u30a2\u30a4\u30bd\u30b6\u30a4\u30e0 (SIRT1\u20147) \u304c\u5b58\u5728\u3057\u3001\u8001\u5316\u3001\u4ee3\u8b1d\u3001\u304c\u3093\u5316\u306a\u3069\u306e\u69d8\u3005\u306a\u751f\u547d\u73fe\u8c61\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306f\u30ea\u30b8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u6d3b\u6027\u306b\u52a0\u3048\u3066\u3001\u30ea\u30b8\u30f3\u6b8b\u57fa\u4e0a\u3067\u304a\u3053\u308b\u69d8\u3005\u306a\u30a2\u30b7\u30eb\u57fa\u3092\u8131\u30a2\u30b7\u30eb\u5316\u3059\u308b\u9175\u7d20\u6d3b\u6027\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u6700\u8fd1\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u30d2\u30c8\u306e\uff17\u7a2e\u985e\u306e\u4e2d\u306e\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306e\u4e2d\u3067\u3082\u4e3b\u306b\u7d30\u80de\u8cea\u306b\u5c40\u5728\u3059\u308bSIRT2\u304c\u3001\u30df\u30ea\u30b9\u30c8\u30a4\u30eb\u57fa\u3084\u30d1\u30eb\u30df\u30c8\u30a4\u30eb\u57fa\u306a\u3069\u306e\u9577\u9396\u30a2\u30b7\u30eb\u57fa\u3092\u8131\u30a2\u30b7\u30eb\u5316\u3059\u308b\u9175\u7d20\u6d3b\u6027\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306fSIRT2\u306b\u6ce8\u76ee\u3057\u3001\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#a03\" data-type=\"URL\">03.\u30ea\u30b8\u30f3\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3092\u6a19\u7684\u3068\u3057\u305f\u5316\u5408\u7269\u63a2\u7d22\u7814\u7a76<\/a><\/h3>\n\n\n\n<p>\u30ea\u30dc\u30be\u30fc\u30e0\u3067\u7ffb\u8a33\u3055\u308c\u305f\u591a\u304f\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7ffb\u8a33\u5f8c\u306b\u69d8\u3005\u306a\u4fee\u98fe\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u304c\u8abf\u7bc0\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4fee\u98fe\u304c\u6b63\u5e38\u306b\u884c\u308f\u308c\u306a\u3044\u3068\u3001\u304c\u3093\u306a\u3069\u306e\u75be\u60a3\u767a\u75c5\u306e\u539f\u56e0\u306b\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4fee\u98fe\u9175\u7d20\u306f\u91cd\u8981\u306a\u5275\u85ac\u5206\u5b50\u6a19\u7684\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6570\u591a\u304f\u3042\u308b\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\u4e2d\u3067\u3082\u3001\u30ea\u30b8\u30f3\u6b8b\u57fa\u4e0a\u3067\u8d77\u3053\u308b\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306f\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3001SUMO\u5316\u3001\u30a2\u30bb\u30c1\u30eb\u5316\u3001\u30e1\u30c1\u30eb\u5316\u306a\u3069\u591a\u7a2e\u591a\u69d8\u3067\u3042\u308a\u3001\u307e\u305f\u3053\u308c\u3089\u4fee\u98fe\u306f\u75be\u60a3\u3068\u5bc6\u63a5\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u3001\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20 (HDAC) \u306e\u963b\u5bb3\u5264\u306f\u6297\u304c\u3093\u5264\u3068\u3057\u3066\u81e8\u5e8a\u306e\u5834\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u7d30\u80de\u306e\u304c\u3093\u5316\u306b\u95a2\u308f\u308b\u30ea\u30b8\u30f3\u4fee\u98fe\u9175\u7d20\u3042\u308b\u3044\u306f\u30ea\u30fc\u30c0\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7740\u76ee\u3057\u3001\u5275\u85ac\u3092\u6307\u5411\u3057\u305f\u5316\u5408\u7269\u63a2\u7d22\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 id=\"01\"><a id=\"a01\"><\/a>01.\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30b8\u30f3\u30a2\u30bb\u30c1\u30eb\u5316\/\u30a2\u30b7\u30eb\u5316\u4fee\u98fe\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"691\" height=\"230\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/\u30a2\u30b7\u30eb.png\" alt=\"\" class=\"wp-image-73\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/\u30a2\u30b7\u30eb.png 691w, https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/\u30a2\u30b7\u30eb-300x100.png 300w\" sizes=\"auto, (max-width: 691px) 100vw, 691px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h5 class=\"wp-block-heading\">\u7814\u7a76\u5185\u5bb9<\/h5>\n\n\n\n<p>\u3000\u8fd1\u5e74\u306e\u8cea\u91cf\u5206\u6790\u88c5\u7f6e\u306e\u767a\u9054\u306a\u3069\u306b\u3088\u308a\u3001\u30d2\u30c8\u306e\u7d30\u80de\u5185\u306b\u306f1,000\u7a2e\u985e\u4ee5\u4e0a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30a2\u30bb\u30c1\u30eb\u5316\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a2\u30bb\u30c1\u30eb\u5316\u306e\u6a5f\u80fd\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u306f\u3054\u304f\u4e00\u90e8\u3067\u3059\u3002\u79c1\u9054\u306f\u3053\u308c\u307e\u3067\u3001\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u7523\u7269\u3067\u3042\u308bp53\u3001\u7ffb\u8a33\u95a2\u9023\u56e0\u5b50\u3067\u3042\u308beIF5A\u3001\u304c\u3093\u306e\u8ee2\u79fb\u3001\u6d78\u6f64\u306b\u91cd\u8981\u306a\u30a2\u30af\u30c1\u30f3\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30b3\u30fc\u30bf\u30af\u30c1\u30f3\u306a\u3069\u3001\u4e3b\u306b\u304c\u3093\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a2\u30bb\u30c1\u30eb\u5316\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\u3001\u30a2\u30bb\u30c1\u30eb\u5316\u306b\u3088\u308b\u305d\u308c\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u5909\u63db\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u5f15\u304d\u7d9a\u304d\u3001\u30a2\u30bb\u30c1\u30eb\u5316\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6a5f\u80fd\u8abf\u7bc0\u306b\u3088\u308b\u7d30\u80de\u6a5f\u80fd\u5236\u5fa1\u3068\u304c\u3093\u306a\u3069\u306e\u75be\u60a3\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304d\u307e\u3059\u3002 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id=\"02\"><a id=\"a02\"><\/a>02.NAD<sup>+<\/sup>\u4f9d\u5b58\u7684\u30ea\u30b8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"670\" height=\"448\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/Sirt2.png\" alt=\"\" class=\"wp-image-86\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/Sirt2.png 670w, https:\/\/www.ls.toyaku.ac.jp\/~cellsig\/wp\/wp-content\/uploads\/Sirt2-300x201.png 300w\" sizes=\"auto, (max-width: 670px) 100vw, 670px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h5 class=\"wp-block-heading\">\u7814\u7a76\u5185\u5bb9<\/h5>\n\n\n\n<p>SIRT2\u4e3b\u306b\u7d30\u80de\u8cea\u306b\u5c40\u5728\u3059\u308bNAD+\u4f9d\u5b58\u7684\u30ea\u30b8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u3067\u3059\u3002\u79c1\u9054\u306fSIRT2\u304c\u7ffb\u8a33\u95a2\u9023\u56e0\u5b50\u3067\u3042\u308beIF5A\u3001\u304c\u3093\u306e\u8ee2\u79fb\u3001\u6d78\u6f64\u306b\u91cd\u8981\u306a\u30a2\u30af\u30c1\u30f3\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30b3\u30fc\u30bf\u30af\u30c1\u30f3\u306e\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3001\u3055\u3089\u306b\u81b5\u81d3\u304c\u3093\u7d30\u80de\u306e\u751f\u5b58\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3001SIRT2\u304c\u5275\u85ac\u5206\u5b50\u6a19\u7684\u306b\u306a\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001SIRT2\u306e\u963b\u5bb3\u7269\u8cea\u306e\u63a2\u7d22\u3092\u884c\u3044\u3001SIRT2\u306e\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u6d3b\u6027\u3092\u9078\u629e\u7684\u306b\u963b\u5bb3\u3059\u308b\u5316\u5408\u7269\u306e\u53d6\u5f97\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u5f97\u3089\u308c\u305f\u963b\u5bb3\u5264\u3068SIRT2\u8907\u5408\u4f53\u306eX\u7dda\u5171\u7d50\u6676\u69cb\u9020\u304b\u3089\u3001SIRT2\u306e\u57fa\u8cea\u7d50\u5408\u90e8\u4f4d\u306e\u5965\u306b\u758e\u6c34\u7684\u306a\u7a7a\u9593\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u5316\u5408\u7269\u306f\u305d\u306e\u758e\u6c34\u7684\u7a7a\u9593\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u758e\u6c34\u7684\u306a\u7a7a\u9593\u306f\u3001\u30df\u30ea\u30b9\u30c8\u30a4\u30eb\u57fa\u3084\u30d1\u30eb\u30df\u30c8\u30a4\u30eb\u57fa\u306a\u3069\u306e\u9577\u9396\u30a2\u30b7\u30eb\u57fa\u304c\u7d50\u5408\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u7a7a\u9593\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001SIRT2\u306e\u30ea\u30b8\u30f3\u8131\u9577\u9396\u30a2\u30b7\u30eb\u5316\u9175\u7d20\u6d3b\u6027\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001SIRT2\u306e\u8131\u9577\u9396\u30a2\u30b7\u30eb\u5316\u9175\u7d20\u306e\u751f\u7406\u7684\u610f\u7fa9\u306f\u5168\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u5206\u5b50\u751f\u7269\u5b66\u3001\u751f\u5316\u5b66\u306e\u624b\u6cd5\u306b\u52a0\u3048\u3066\u3001\u5316\u5408\u7269\u3092\u7528\u3044\u3066\u751f\u547d\u73fe\u8c61\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001SIRT2\u306e\u30ea\u30b8\u30f3\u8131\u9577\u9396\u30a2\u30b7\u30eb\u5316\u9175\u7d20\u306e\u7d30\u80de\u5185\u3067\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 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Welcome! \u3053\u3093\u306b\u3061\u306f\u3002\u79c1\u305f\u3061\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3092\u8a2a\u308c\u3066\u3044\u305f\u3060\u304d\u6709\u96e3\u3046\u3054\u3056\u3044\u307e\u3059\u3002 \u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u751f\u5316\u5b66\u7684\u3001\u7d30\u80de\u751f\u7269\u5b66\u7684\u3001\u907a\u4f1d\u5b66\u7684\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u7ffb\u8a33\u5f8c\u4fee\u98fe\u95a2\u9023\u9175\u7d20\u3001\u304c\u3093\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8 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