{"id":178,"date":"2016-05-01T13:27:36","date_gmt":"2016-05-01T04:27:36","guid":{"rendered":"http:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/?page_id=178"},"modified":"2026-04-10T15:56:02","modified_gmt":"2026-04-10T06:56:02","slug":"home","status":"publish","type":"page","link":"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/","title":{"rendered":"10\u5e74\u5148\u300120\u5e74\u5148\u306e\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3068\u306a\u308b\u5206\u6790\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066"},"content":{"rendered":"\n<ul>\n<li>\n<h2><a href=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/planetary\/\"><b>\u4eba\u306e\u5fc3\u3068\u5065\u5eb7\u3092\u5b88\u308b\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/b>\u3092\u5c55\u958b\u3057\u307e\u3059<\/a><\/h2>\n<\/li>\n<li>\n<h2><a 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300w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2026\/02\/S__524255281-1024x530.jpg 1024w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2026\/02\/S__524255281-768x397.jpg 768w\" sizes=\"auto, (max-width: 1318px) 100vw, 1318px\" \/><\/a><figcaption class=\"wp-element-caption\">2025\u5e74\u5ea6\u5352\u696d\u7814\u7a76\u767a\u8868\u4f1a (2026.2.19)<\/figcaption><\/figure>\n<\/div>\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-4 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/home\/fd081768299da224c8c8ebb7bf3ef299\/\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"400\" data-id=\"1240\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2024\/05\/fd081768299da224c8c8ebb7bf3ef299.jpg\" alt=\"\" class=\"wp-image-1240\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2024\/05\/fd081768299da224c8c8ebb7bf3ef299.jpg 800w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2024\/05\/fd081768299da224c8c8ebb7bf3ef299-300x150.jpg 300w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2024\/05\/fd081768299da224c8c8ebb7bf3ef299-768x384.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\">2023\u5e74\u5ea6\u5352\u696d\u8ad6\u6587\u767a\u8868\u4f1a(2024.2.19)<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/blog\/2021\/03\/01\/2020%e5%b9%b4%e5%ba%a6%e4%bf%ae%e5%a3%ab%e8%ab%96%e6%96%87%e7%99%ba%e8%a1%a8%e4%bc%9a%e3%81%8c%e3%82%aa%e3%83%b3%e3%83%a9%e3%82%a4%e3%83%b3%e3%81%a7%e9%96%8b%e5%82%ac%e3%81%95%e3%82%8c%e3%81%be\/%e5%8d%92%e8%ab%96%e7%99%ba%e8%a1%a82020\/\"><img loading=\"lazy\" decoding=\"async\" width=\"645\" height=\"360\" data-id=\"1124\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2021\/03\/1ed1216d6ce3343143eebcf4cf1bc2d4.png\" alt=\"\" class=\"wp-image-1124\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2021\/03\/1ed1216d6ce3343143eebcf4cf1bc2d4.png 645w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2021\/03\/1ed1216d6ce3343143eebcf4cf1bc2d4-300x167.png 300w\" sizes=\"auto, (max-width: 645px) 100vw, 645px\" \/><\/a><figcaption class=\"wp-element-caption\">2020\u5e74\u5ea6\u4fee\u58eb\u8ad6\u6587\u767a\u8868\u4f1a 2021.2.26<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/blog\/2020\/04\/10\/%e6%96%b0%e5%b9%b4%e5%ba%a6%e3%81%af%e3%82%aa%e3%83%b3%e3%83%a9%e3%82%a4%e3%83%b3%e3%82%bb%e3%83%9f%e3%83%8a%e3%83%bc%e3%81%a7%e3%82%b9%e3%82%bf%e3%83%bc%e3%83%88%e3%81%97%e3%81%be%e3%81%97%e3%81%9f\/2020seminar\/\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" data-id=\"1081\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2020\/04\/2020seminar.jpg\" alt=\"\" class=\"wp-image-1081\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2020\/04\/2020seminar.jpg 600w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2020\/04\/2020seminar-300x200.jpg 300w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2020\/04\/2020seminar-75x50.jpg 75w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2020\/04\/2020seminar-272x182.jpg 272w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><figcaption class=\"wp-element-caption\">2020\u5e74\u5ea6 \u7814\u7a76\u5ba4\u30bc\u30df\u958b\u59cb\u30002020.4.7<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/blog\/2019\/07\/11\/plasma2019\/img_0958s\/\"><img loading=\"lazy\" decoding=\"async\" width=\"887\" height=\"1024\" data-id=\"956\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2019\/07\/IMG_0958s-887x1024.jpg\" alt=\"\" class=\"wp-image-956\" srcset=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2019\/07\/IMG_0958s-887x1024.jpg 887w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2019\/07\/IMG_0958s-260x300.jpg 260w, https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2019\/07\/IMG_0958s-768x886.jpg 768w\" sizes=\"auto, (max-width: 887px) 100vw, 887px\" \/><\/a><figcaption class=\"wp-element-caption\">2019\u7b51\u6ce2\u30bb\u30df\u30ca\u30fc 2019.7.11-12<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b9\u30bf\u30c3\u30d5<\/h3>\n\n\n\n<div id='gallery-2' class='gallery galleryid-178 gallery-columns-4 gallery-size-thumbnail'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href=\"http:\/\/www.ls.toyaku.ac.jp\/~tumemura\/home.html\" class=\"no-lightbox\"><img loading=\"lazy\" decoding=\"async\" width=\"120\" height=\"150\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2015\/08\/umemura-120x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" aria-describedby=\"gallery-2-157\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-157'>\n\t\t\t\t\u6559\u6388\u3000\u6885\u6751\u3000\u77e5\u4e5f\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon 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aria-describedby=\"gallery-2-161\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-161'>\n\t\t\t\t\u8b1b\u5e2b\u3000\u718a\u7530 \u82f1\u5cf0\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/aoki\/\" class=\"no-lightbox\"><img loading=\"lazy\" decoding=\"async\" width=\"120\" height=\"150\" src=\"https:\/\/www.ls.toyaku.ac.jp\/~bioanalchem\/cms\/wp-content\/uploads\/2015\/08\/aoki-120x150.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" aria-describedby=\"gallery-2-160\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-160'>\n\t\t\t\t\u52a9\u6559\u3000\u9752\u6728 \u5143\u79c0\n\t\t\t\t<\/figcaption><\/figure>\n\t\t<\/div>\n\n<div style=\"text-align: center;\"><strong><span style=\"color: #800080;\">\u2191 \u2191 \u5404\u30b9\u30bf\u30c3\u30d5\u306e\u30da\u30fc\u30b8\u306f\u5199\u771f\u3092\u30af\u30ea\u30c3\u30af \u2191 \u2191<\/span><\/strong><\/div>\n<div>\u00a0<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u8ad6\u6587\u767a\u8868\uff08\u6700\u8fd1\uff13\u5e74\u9593\uff09<\/h3>\n\n\n<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\"><a name=\"tppubs\" id=\"tppubs\"><\/a><\/form><div class=\"teachpress_publication_list\"><h3 class=\"tp_h3\" id=\"tp_h3_2025\">2025<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Kumata, Hidetoshi;  Ochiai, Haruka;  Tanaka, Anna;  Oda, Shiori;  Ishikawa-Takata, Kazuko;  Umemura, Tomonari<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('183','tp_links')\" style=\"cursor:pointer;\">Simple analytical method to determine urinary isotopic enrichment of phenylalanine by GC\/EI-MS coupled with pentafluorobenzyl derivatization<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <span class=\"tp_pub_label_status forthcoming\">Forthcoming<\/span><\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Talanta, <\/span><span class=\"tp_pub_additional_volume\">vol. 287, <\/span>Forthcoming.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_183\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('183','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_183\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('183','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_183\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('183','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_183\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Simple analytical method to determine urinary isotopic enrichment of phenylalanine by GC\/EI-MS coupled with pentafluorobenzyl derivatization},<br \/>\r\nauthor = {Hidetoshi Kumata and Haruka Ochiai and Anna Tanaka and Shiori Oda and Kazuko Ishikawa-Takata and Tomonari Umemura},<br \/>\r\ndoi = {10.1016\/j.talanta.2025.127697},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-05-15},<br \/>\r\nurldate = {2025-05-15},<br \/>\r\njournal = {Talanta},<br \/>\r\nvolume = {287},<br \/>\r\nabstract = {The indicator amino acid oxidation (IAAO) technique estimates the physiological requirements for amino acids and proteins in living organisms, including humans. It involves monitoring urinary amino acids and exhaled CO2 after ingesting 1-13C-labeled (carboxy-labeled) amino acids. The most common IAAO indicator amino acid is 1-13C-labeled phenylalanine ([1-13C]Phe). Its urinary concentration in test subjects ranges from below the detection limit to several \u03bcM. A simple analytical method for distinguishing trace amounts of [1-13C]Phe in urine from high levels of naturally occurring Phe is crucial for making IAAO tests easier. This study presents a simple and reliable approach for the simultaneous quantification of [1-13C]Phe and Phe in human urine using conventional GC-EI-MS. In this method, urinary phenylalanine is reacted with pentafluorobenzyl bromide in a single-phase solvent system of acetone-borate buffer without dehydration or desalting to form disubstituted pentafluorobenzyl (PFB) derivatives, which are then analyzed by GC-EI-MS (SIM). The Phe and [1-13C]Phe PFB derivative peaks eluted at the same retention time on the gas chromatogram but could be differentiated on the basis of fragment ions (m\/z 434, 435) derived from the loss of the phenyl group ([M \u2212 91]+). Correcting the interference of the m+1 isotope peak of Phe in the [M \u2212 91] fragment (m\/z 435) of [1-13C]Phe using the m\/z 434 peak intensity and natural isotope ratio, both Phe and [1-13C]Phe could be quantified in the concentration range found in urine. The method was successfully applied to examine the temporal enrichment of [1-13C]Phe in urine samples obtained from IAAO subjects following the ingestion of a test meal containing [1-13C]Phe.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {forthcoming},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('183','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_183\" style=\"display:none;\"><div class=\"tp_abstract_entry\">The indicator amino acid oxidation (IAAO) technique estimates the physiological requirements for amino acids and proteins in living organisms, including humans. It involves monitoring urinary amino acids and exhaled CO2 after ingesting 1-13C-labeled (carboxy-labeled) amino acids. The most common IAAO indicator amino acid is 1-13C-labeled phenylalanine ([1-13C]Phe). Its urinary concentration in test subjects ranges from below the detection limit to several \u03bcM. A simple analytical method for distinguishing trace amounts of [1-13C]Phe in urine from high levels of naturally occurring Phe is crucial for making IAAO tests easier. This study presents a simple and reliable approach for the simultaneous quantification of [1-13C]Phe and Phe in human urine using conventional GC-EI-MS. In this method, urinary phenylalanine is reacted with pentafluorobenzyl bromide in a single-phase solvent system of acetone-borate buffer without dehydration or desalting to form disubstituted pentafluorobenzyl (PFB) derivatives, which are then analyzed by GC-EI-MS (SIM). The Phe and [1-13C]Phe PFB derivative peaks eluted at the same retention time on the gas chromatogram but could be differentiated on the basis of fragment ions (m\/z 434, 435) derived from the loss of the phenyl group ([M \u2212 91]+). Correcting the interference of the m+1 isotope peak of Phe in the [M \u2212 91] fragment (m\/z 435) of [1-13C]Phe using the m\/z 434 peak intensity and natural isotope ratio, both Phe and [1-13C]Phe could be quantified in the concentration range found in urine. The method was successfully applied to examine the temporal enrichment of [1-13C]Phe in urine samples obtained from IAAO subjects following the ingestion of a test meal containing [1-13C]Phe.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('183','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_183\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1016\/j.talanta.2025.127697\" title=\"Follow DOI:10.1016\/j.talanta.2025.127697\" target=\"_blank\">doi:10.1016\/j.talanta.2025.127697<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('183','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> \u9752\u6728, \u5143\u79c0<\/p><p class=\"tp_pub_title\">\u30ea\u30d4\u30c9\u30df\u30af\u30b9\u3067\u7d10\u89e3\u304f\u7d30\u80de\u5185\u5171\u751f\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9 \u2015\u751f\u4f53\u819c\u8102\u8cea\u306e\u52d5\u614b\u89e3\u6790\u304b\u3089\u5171\u751f\u6210\u7acb\u306e\u9375\u3092\u63a2\u308b <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">\u7d30\u80de, <\/span><span class=\"tp_pub_additional_volume\">vol. 57, <\/span><span class=\"tp_pub_additional_issue\">iss. 5, <\/span><span class=\"tp_pub_additional_pages\">pp. 80-81, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1346-7557<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_185\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('185','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_185\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokeyj,<br \/>\r\ntitle = {\u30ea\u30d4\u30c9\u30df\u30af\u30b9\u3067\u7d10\u89e3\u304f\u7d30\u80de\u5185\u5171\u751f\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9 \u2015\u751f\u4f53\u819c\u8102\u8cea\u306e\u52d5\u614b\u89e3\u6790\u304b\u3089\u5171\u751f\u6210\u7acb\u306e\u9375\u3092\u63a2\u308b},<br \/>\r\nauthor = {\u5143\u79c0 \u9752\u6728},<br \/>\r\nissn = {1346-7557},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-03-31},<br \/>\r\nurldate = {2025-03-31},<br \/>\r\njournal = {\u7d30\u80de},<br \/>\r\nvolume = {57},<br \/>\r\nissue = {5},<br \/>\r\npages = {80-81},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('185','tp_bibtex')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Ito, Ryo;  Endo, Mizuki;  Aoki, Motohide;  Fujiwara, Shoko;  Sato, Norihiro<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('184','tp_links')\" style=\"cursor:pointer;\">Evolutionary conservation of acylplastoquinone species from cyanobacteria to eukaryotic photosynthetic organisms of green and red lineages<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Frontiers in Plant Science, <\/span><span class=\"tp_pub_additional_volume\">vol. Volume 16 - 2025, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1664-462X<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_resource_link\"><a id=\"tp_links_sh_184\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('184','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_184\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('184','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_184\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{10.3389\/fpls.2025.1569038,<br \/>\r\ntitle = {Evolutionary conservation of acylplastoquinone species from cyanobacteria to eukaryotic photosynthetic organisms of green and red lineages},<br \/>\r\nauthor = {Ryo Ito and Mizuki Endo and Motohide Aoki and Shoko Fujiwara and Norihiro Sato},<br \/>\r\nurl = {https:\/\/www.frontiersin.org\/journals\/plant-science\/articles\/10.3389\/fpls.2025.1569038},<br \/>\r\ndoi = {10.3389\/fpls.2025.1569038},<br \/>\r\nissn = {1664-462X},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\njournal = {Frontiers in Plant Science},<br \/>\r\nvolume = {Volume 16 - 2025},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('184','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_184\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.frontiersin.org\/journals\/plant-science\/articles\/10.3389\/fpls.2025.1569038\" title=\"https:\/\/www.frontiersin.org\/journals\/plant-science\/articles\/10.3389\/fpls.2025.15[...]\" target=\"_blank\">https:\/\/www.frontiersin.org\/journals\/plant-science\/articles\/10.3389\/fpls.2025.15[...]<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.3389\/fpls.2025.1569038\" title=\"Follow DOI:10.3389\/fpls.2025.1569038\" target=\"_blank\">doi:10.3389\/fpls.2025.1569038<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('184','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><\/div><\/div>\n\n\n<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\"><a name=\"tppubs\" id=\"tppubs\"><\/a><\/form><div class=\"teachpress_publication_list\"><h3 class=\"tp_h3\" id=\"tp_h3_2024\">2024<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> KUMATA, Hidetoshi;  UCHIDA, Masao;  SAHA, Mahua;  SAITOH, Shoichi;  MANTOKU, Kanako;  KOBAYASHI, Toshiyuki;  OKUDA, Tomoaki;  NAKAJIMA, Fumiyuki;  HATAKEYAMA, Shiro;  SHIBATA, Yasuyuki;  TAKADA, Hideshige<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('180','tp_links')\" style=\"cursor:pointer;\">Source apportionment of atmospheric and sedimentary PAHs from Kolkata, India using compound-class-specific radiocarbon analysis (CCSRA)<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Radiocarbon, <\/span><span class=\"tp_pub_additional_volume\">vol. 66, <\/span><span class=\"tp_pub_additional_issue\">iss. 5, <\/span><span class=\"tp_pub_additional_pages\">pp. 892-903, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_180\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('180','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_180\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('180','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_180\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('180','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_180\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Source apportionment of atmospheric and sedimentary PAHs from Kolkata, India using compound-class-specific radiocarbon analysis (CCSRA)},<br \/>\r\nauthor = {Hidetoshi KUMATA and Masao UCHIDA and Mahua SAHA and Shoichi SAITOH and Kanako<br \/>\r\n MANTOKU and Toshiyuki KOBAYASHI and Tomoaki OKUDA and Fumiyuki NAKAJIMA and Shiro<br \/>\r\n HATAKEYAMA and Yasuyuki SHIBATA and Hideshige TAKADA},<br \/>\r\nurl = {https:\/\/doi.org\/10.1017\/RDC.2024.66},<br \/>\r\ndoi = {10.1017\/RDC.2024.66},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-09-18},<br \/>\r\nurldate = {2024-09-24},<br \/>\r\njournal = {Radiocarbon},<br \/>\r\nvolume = {66},<br \/>\r\nissue = {5},<br \/>\r\npages = {892-903},<br \/>\r\nabstract = {Polycyclic aromatic hydrocarbons (PAHs) are major air pollutants that are ubiquitously produced by the combustion of organic materials, and it is extremely important to identify their pollution sources. In this study, molecular fingerprinting and compound class-specific radiocarbon dating (CCSRA) were performed on PAHs from canal sediments and air samples collected in Kolkata, India\u2019s third largest city (population approximately 16 million), where PAHs pollution has been a serious problem. Average PAH (\u03a312-parent PAHs) concentrations in air samples were 65.1 ng m\u20133 in summer and 70.9 ng m\u20133 in winter and in canal sediments were 32.7 \u00b5g g\u20131, which are classified as \u201cvery high-level\u201d pollution. Molecular fingerprinting using methyl-PAH\/PAH (MPAHs\/PAHs) ratios and isomer pair ratios with molecular weights of 178, 202, 228, and 276 suggested that wood and coal combustion were the dominant sources of PAHs in the sediment, and that atmospheric PAHs were influenced by oil combustion in addition to them. The fraction of contemporary carbon (\u0192C) of sedimentary PAHs (0.056\u20130.100), together with the extremely low MPAHs\/PAHs ratio results, lead to the conclusion that the major source of the high concentration of PAHs in the canals is from coal combustion. On the other hand, the \u0192C of atmospheric PAHs (0.272\u20130.369) was close to the share of biomass fuels in India\u2019s domestic fuel consumption in 2011 (about 35%). Furthermore, the observed \u0192C-discrepancy between atmospheric and sedimentary PAHs in the same urban environment was interpreted to give an insight into the loading pathway of PAHs to canal sediments in Kolkata.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('180','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_180\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Polycyclic aromatic hydrocarbons (PAHs) are major air pollutants that are ubiquitously produced by the combustion of organic materials, and it is extremely important to identify their pollution sources. In this study, molecular fingerprinting and compound class-specific radiocarbon dating (CCSRA) were performed on PAHs from canal sediments and air samples collected in Kolkata, India\u2019s third largest city (population approximately 16 million), where PAHs pollution has been a serious problem. Average PAH (\u03a312-parent PAHs) concentrations in air samples were 65.1 ng m\u20133 in summer and 70.9 ng m\u20133 in winter and in canal sediments were 32.7 \u00b5g g\u20131, which are classified as \u201cvery high-level\u201d pollution. Molecular fingerprinting using methyl-PAH\/PAH (MPAHs\/PAHs) ratios and isomer pair ratios with molecular weights of 178, 202, 228, and 276 suggested that wood and coal combustion were the dominant sources of PAHs in the sediment, and that atmospheric PAHs were influenced by oil combustion in addition to them. The fraction of contemporary carbon (\u0192C) of sedimentary PAHs (0.056\u20130.100), together with the extremely low MPAHs\/PAHs ratio results, lead to the conclusion that the major source of the high concentration of PAHs in the canals is from coal combustion. On the other hand, the \u0192C of atmospheric PAHs (0.272\u20130.369) was close to the share of biomass fuels in India\u2019s domestic fuel consumption in 2011 (about 35%). Furthermore, the observed \u0192C-discrepancy between atmospheric and sedimentary PAHs in the same urban environment was interpreted to give an insight into the loading pathway of PAHs to canal sediments in Kolkata.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('180','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_180\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/doi.org\/10.1017\/RDC.2024.66\" title=\"https:\/\/doi.org\/10.1017\/RDC.2024.66\" target=\"_blank\">https:\/\/doi.org\/10.1017\/RDC.2024.66<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1017\/RDC.2024.66\" title=\"Follow DOI:10.1017\/RDC.2024.66\" target=\"_blank\">doi:10.1017\/RDC.2024.66<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('180','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_inbook\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> \u9752\u6728, \u5143\u79c0;  \u6731, \u5f66\u5317;  \u6c96\u91ce, \u6643\u4fca;  \u6885\u6751, \u77e5\u4e5f<\/p><p class=\"tp_pub_title\">UV\u30ca\u30ce\u30a4\u30f3\u30d7\u30ea\u30f3\u30c8\u6280\u8853\u3092\u5229\u7528\u3057\u305fLA-ICP-MS\u5358\u4e00\u7d30\u80de\u5143\u7d20\u5206\u6790\u7528\u8a66\u6599\u5c0e\u5165\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a <span class=\"tp_pub_type tp_  inbook\">Book Chapter<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_booktitle\">\u30ca\u30ce\u30a4\u30f3\u30d7\u30ea\u30f3\u30c8 \u2015\u6b21\u4e16\u4ee3\u5fae\u7d30\u52a0\u5de5\u6280\u8853\u306e\u6700\u524d\u7dda\u2015\r\nNanoimprint : Find Upcoming New Footing!, <\/span><span class=\"tp_pub_additional_chapter\"> Chapter 9, <\/span><span class=\"tp_pub_additional_pages\">pp. 208\u2013216, <\/span><span class=\"tp_pub_additional_publisher\">\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>, <span class=\"tp_pub_additional_isbn\">ISBN: 978-4-7813-1810-3<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_179\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('179','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_179\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@inbook{nokey,<br \/>\r\ntitle = {UV\u30ca\u30ce\u30a4\u30f3\u30d7\u30ea\u30f3\u30c8\u6280\u8853\u3092\u5229\u7528\u3057\u305fLA-ICP-MS\u5358\u4e00\u7d30\u80de\u5143\u7d20\u5206\u6790\u7528\u8a66\u6599\u5c0e\u5165\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a},<br \/>\r\nauthor = {\u9752\u6728,\u5143\u79c0 and \u6731,\u5f66\u5317 and \u6c96\u91ce,\u6643\u4fca and \u6885\u6751,\u77e5\u4e5f},<br \/>\r\nisbn = {978-4-7813-1810-3},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-07-18},<br \/>\r\nurldate = {2024-07-18},<br \/>\r\nbooktitle = {\u30ca\u30ce\u30a4\u30f3\u30d7\u30ea\u30f3\u30c8 \u2015\u6b21\u4e16\u4ee3\u5fae\u7d30\u52a0\u5de5\u6280\u8853\u306e\u6700\u524d\u7dda\u2015<br \/>\r\nNanoimprint : Find Upcoming New Footing!},<br \/>\r\npages = {208\u2013216},<br \/>\r\npublisher = {\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248},<br \/>\r\nchapter = {9},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {inbook}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('179','tp_bibtex')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_proceedings\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> \u718a\u7530, \u82f1\u5cf0;  \u5185\u7530, \u660c\u7537;  SAHA, Mahua;  \u6589\u85e4, \u7965\u4e00;  \u4e07\u5fb3, \u4f73\u83dc\u5b50;  \u5965\u7530, \u77e5\u660e;  \u4e2d\u5cf6, \u5178\u4e4b;  \u7560\u5c71, \u53f2\u90ce;  \u9ad8\u7530, \u79c0\u91cd<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('181','tp_links')\" style=\"cursor:pointer;\">\u9ad8\u6fc3\u5ea6\u6c5a\u67d3\u90fd\u5e02\u30a4\u30f3\u30c9\u30b3\u30eb\u30ab\u30bf\u74b0\u5883\u306b\u304a\u3051\u308b\u5927\u6c17\u2212\u5806\u7a4d\u7269\u4e2dPAHs\u306e14C\u30ec\u30d9\u30eb\u4e56\u96e2<\/a> <span class=\"tp_pub_type tp_  proceedings\">Proceedings<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_organization\">\u65e5\u672cAMS\u7814\u7a76\u5354\u4f1a <\/span><span class=\"tp_pub_additional_publisher\">\u65e5\u672cAMS\u7814\u7a76\u5354\u4f1a, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_resource_link\"><a id=\"tp_links_sh_181\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('181','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_181\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('181','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_181\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@proceedings{nokey,<br \/>\r\ntitle = {\u9ad8\u6fc3\u5ea6\u6c5a\u67d3\u90fd\u5e02\u30a4\u30f3\u30c9\u30b3\u30eb\u30ab\u30bf\u74b0\u5883\u306b\u304a\u3051\u308b\u5927\u6c17\u2212\u5806\u7a4d\u7269\u4e2dPAHs\u306e14C\u30ec\u30d9\u30eb\u4e56\u96e2},<br \/>\r\nauthor = {\u718a\u7530, \u82f1\u5cf0 and \u5185\u7530, \u660c\u7537 and Mahua SAHA and \u6589\u85e4, \u7965\u4e00 and \u4e07\u5fb3, \u4f73\u83dc\u5b50 and \u5965\u7530, \u77e5\u660e and \u4e2d\u5cf6, \u5178\u4e4b and \u7560\u5c71, \u53f2\u90ce and \u9ad8\u7530, \u79c0\u91cd},<br \/>\r\nurl = {https:\/\/malt.um.u-tokyo.ac.jp\/jmas-24-proceedings\/},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-06-03},<br \/>\r\nurldate = {2024-06-03},<br \/>\r\nbooktitle = {\u7b2c24\u56deAMS\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30d7\u30ed\u30b7\u30fc\u30c7\u30a3\u30f3\u30b0\u30ba},<br \/>\r\npublisher = {\u65e5\u672cAMS\u7814\u7a76\u5354\u4f1a},<br \/>\r\norganization = {\u65e5\u672cAMS\u7814\u7a76\u5354\u4f1a},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {proceedings}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('181','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_181\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/malt.um.u-tokyo.ac.jp\/jmas-24-proceedings\/\" title=\"https:\/\/malt.um.u-tokyo.ac.jp\/jmas-24-proceedings\/\" target=\"_blank\">https:\/\/malt.um.u-tokyo.ac.jp\/jmas-24-proceedings\/<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('181','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Ogawa, Tadayuki;  Homma-Takeda, Shino;  Umemura, Tomonari;  Hirata, Takafumi;  Saito, Yuko<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('186','tp_links')\" style=\"cursor:pointer;\">Molecular environment in Alzheimer\u2019s disease brain revealed by the hybrid imaging analyses<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Alzheimer's &amp; Dementia, <\/span><span class=\"tp_pub_additional_volume\">vol. 20, <\/span><span class=\"tp_pub_additional_number\">no. S1, <\/span><span class=\"tp_pub_additional_pages\">pp. e093362, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_186\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('186','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_186\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('186','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_186\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('186','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_186\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{https:\/\/doi.org\/10.1002\/alz.093362,<br \/>\r\ntitle = {Molecular environment in Alzheimer\u2019s disease brain revealed by the hybrid imaging analyses},<br \/>\r\nauthor = {Tadayuki Ogawa and Shino Homma-Takeda and Tomonari Umemura and Takafumi Hirata and Yuko Saito},<br \/>\r\nurl = {https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/alz.093362},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1002\/alz.093362},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-01-01},<br \/>\r\njournal = {Alzheimer's & Dementia},<br \/>\r\nvolume = {20},<br \/>\r\nnumber = {S1},<br \/>\r\npages = {e093362},<br \/>\r\nabstract = {Abstract Background Although amyloid deposition in brain is one of the hallmark pathological features of Alzheimer\u2019s disease (AD), the upstream events and its molecular environment in AD brain remain largely unknown. Recent advances in analytical methods such as mass spectrometry can provide the cutting-edge tools to unveil the AD pathogenesis at molecular and atomic level. Method In order to gain the comprehensive information about AD pathology at molecular level, postmortem brain sections of AD patients were analyzed by the hybrid molecular imaging methods composed of the conventional histological analyses, matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) for small molecules, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging for metals, and particle induced X-ray emission (PIXE) imaging for elements. Principal components analysis (PCA) was also applied to discover the differences between the spectra datasets of AD and healthy control brains. Specific distribution of molecules and elements were visualized on the brain slice. (Ethics Approval: Dokkyo Medical University No.2021-004, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology No.R20-003). Result MALDI-MSI showed abnormal distribution of lipids, such as phospholipids, sphingolipids, and their derivatives in AD brain. LA-ICP-MS visualized the distribution of elements, including some metals in the wide-field brain section. PIXE imaging displayed the specific concentration of atoms nearby the pathological tangles detected by anti-ubiquitin antibody. PCA proposed the effective classification to distinguish AD from control based on mass spectra. Conclusion Our data suggest the molecular and atomic environment in brain that is closely linked to AD pathology. Further analyses should be conducted to elucidate the fundamental mechanism of AD pathogenesis and prevention.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('186','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_186\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Abstract Background Although amyloid deposition in brain is one of the hallmark pathological features of Alzheimer\u2019s disease (AD), the upstream events and its molecular environment in AD brain remain largely unknown. Recent advances in analytical methods such as mass spectrometry can provide the cutting-edge tools to unveil the AD pathogenesis at molecular and atomic level. Method In order to gain the comprehensive information about AD pathology at molecular level, postmortem brain sections of AD patients were analyzed by the hybrid molecular imaging methods composed of the conventional histological analyses, matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) for small molecules, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging for metals, and particle induced X-ray emission (PIXE) imaging for elements. Principal components analysis (PCA) was also applied to discover the differences between the spectra datasets of AD and healthy control brains. Specific distribution of molecules and elements were visualized on the brain slice. (Ethics Approval: Dokkyo Medical University No.2021-004, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology No.R20-003). Result MALDI-MSI showed abnormal distribution of lipids, such as phospholipids, sphingolipids, and their derivatives in AD brain. LA-ICP-MS visualized the distribution of elements, including some metals in the wide-field brain section. PIXE imaging displayed the specific concentration of atoms nearby the pathological tangles detected by anti-ubiquitin antibody. PCA proposed the effective classification to distinguish AD from control based on mass spectra. Conclusion Our data suggest the molecular and atomic environment in brain that is closely linked to AD pathology. Further analyses should be conducted to elucidate the fundamental mechanism of AD pathogenesis and prevention.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('186','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_186\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/alz.093362\" title=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/alz.093362\" target=\"_blank\">https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/alz.093362<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1002\/alz.093362\" title=\"Follow DOI:https:\/\/doi.org\/10.1002\/alz.093362\" target=\"_blank\">doi:https:\/\/doi.org\/10.1002\/alz.093362<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('186','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><\/div><\/div>\n\n\n<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\"><a name=\"tppubs\" id=\"tppubs\"><\/a><\/form><div class=\"teachpress_publication_list\"><h3 class=\"tp_h3\" id=\"tp_h3_2023\">2023<\/h3><div class=\"tp_publication tp_publication_booklet\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> \u718a\u7530, \u82f1\u5cf0<\/p><p class=\"tp_pub_title\">\u591a\u74b0\u82b3\u9999\u65cf\u70ad\u5316\u6c34\u7d20\u306b\u3088\u308b\u6c5a\u67d3\u306e\u5909\u9077 <span class=\"tp_pub_type tp_  booklet\">Booklet<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_year\">2023<\/span>, <span class=\"tp_pub_additional_isbn\">ISBN: 0018-3342\/23<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_182\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('182','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_182\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@booklet{nokey,<br \/>\r\ntitle = {\u591a\u74b0\u82b3\u9999\u65cf\u70ad\u5316\u6c34\u7d20\u306b\u3088\u308b\u6c5a\u67d3\u306e\u5909\u9077},<br \/>\r\nauthor = {\u718a\u7530, \u82f1\u5cf0},<br \/>\r\neditor = {\u5409\u6c38, \u6df3},<br \/>\r\nisbn = {0018-3342\/23},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-06-01},<br \/>\r\nurldate = {2023-06-01},<br \/>\r\njournal = {\u4fdd\u5065\u306e\u79d1\u5b66},<br \/>\r\nvolume = {65},<br \/>\r\npages = {387-393},<br \/>\r\nmonth = {06},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {booklet}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('182','tp_bibtex')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Miki, Yuta;  Murakami, Hiroya;  Gotoh, Marin;  Umemura, Tomonari;  Esaka, Yukihiro;  Inoue, Yoshinori;  Teshima, Norio<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('174','tp_links')\" style=\"cursor:pointer;\">Novel chemically cross-linked self-molding particulate sorbents as solid-phase extraction media<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Anal Sci, <\/span><span class=\"tp_pub_additional_volume\">vol. 39, <\/span><span class=\"tp_pub_additional_number\">no. 5, <\/span><span class=\"tp_pub_additional_pages\">pp. 749\u2013754, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1348-2246<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_174\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('174','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_174\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('174','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_174\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('174','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_174\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{pmid36001293,<br \/>\r\ntitle = {Novel chemically cross-linked self-molding particulate sorbents as solid-phase extraction media},<br \/>\r\nauthor = {Yuta Miki and Hiroya Murakami and Marin Gotoh and Tomonari Umemura and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},<br \/>\r\ndoi = {10.1007\/s44211-022-00179-3},<br \/>\r\nissn = {1348-2246},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-05-01},<br \/>\r\njournal = {Anal Sci},<br \/>\r\nvolume = {39},<br \/>\r\nnumber = {5},<br \/>\r\npages = {749--754},<br \/>\r\nabstract = {Here, we describe novel, chemically cross-linked, self-molding particulate polymer sorbents that are utilized as a molding-type solid-phase extraction medium (M-SPEM), which exhibits high permeability and rigidness. To fabricate such M-SPEM, first, polyethyleneimine (PEI)-modified reversed-phase (RP)-type particulate sorbents were synthesized, thereafter, they were chemically cross-linked by a polymer having many epoxy groups together with additional PEI. By optimizing the binding conditions of the particulate sorbents, the resultant M-SPEM has almost the same adsorption properties as the corresponding unmolded particulate sorbent for some polar (e.g., uracil and adenine) compounds. The binding technique proposed here is expected to facilitate the fabrication of molding-type sorbents and improve the performance of the SPE procedure.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('174','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_174\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Here, we describe novel, chemically cross-linked, self-molding particulate polymer sorbents that are utilized as a molding-type solid-phase extraction medium (M-SPEM), which exhibits high permeability and rigidness. To fabricate such M-SPEM, first, polyethyleneimine (PEI)-modified reversed-phase (RP)-type particulate sorbents were synthesized, thereafter, they were chemically cross-linked by a polymer having many epoxy groups together with additional PEI. By optimizing the binding conditions of the particulate sorbents, the resultant M-SPEM has almost the same adsorption properties as the corresponding unmolded particulate sorbent for some polar (e.g., uracil and adenine) compounds. The binding technique proposed here is expected to facilitate the fabrication of molding-type sorbents and improve the performance of the SPE procedure.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('174','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_174\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1007\/s44211-022-00179-3\" title=\"Follow DOI:10.1007\/s44211-022-00179-3\" target=\"_blank\">doi:10.1007\/s44211-022-00179-3<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('174','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Murakami, Hiroya;  Iida, Keisuke;  Oda, Yuki;  Umemura, Tomonari;  Nakajima, Hizuru;  Esaka, Yukihiro;  Inoue, Yoshinori;  Teshima, Norio<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('173','tp_links')\" style=\"cursor:pointer;\">Hydrophilic interaction chromatography-type sorbent prepared by the modification of methacrylate-base resin with polyethyleneimine for solid-phase extraction of polar compounds<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Anal Sci, <\/span><span class=\"tp_pub_additional_volume\">vol. 39, <\/span><span class=\"tp_pub_additional_number\">no. 3, <\/span><span class=\"tp_pub_additional_pages\">pp. 375\u2013381, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1348-2246<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_173\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('173','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_173\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('173','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_173\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('173','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_173\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{pmid36577893,<br \/>\r\ntitle = {Hydrophilic interaction chromatography-type sorbent prepared by the modification of methacrylate-base resin with polyethyleneimine for solid-phase extraction of polar compounds},<br \/>\r\nauthor = {Hiroya Murakami and Keisuke Iida and Yuki Oda and Tomonari Umemura and Hizuru Nakajima and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},<br \/>\r\ndoi = {10.1007\/s44211-022-00250-z},<br \/>\r\nissn = {1348-2246},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-03-01},<br \/>\r\njournal = {Anal Sci},<br \/>\r\nvolume = {39},<br \/>\r\nnumber = {3},<br \/>\r\npages = {375--381},<br \/>\r\nabstract = {Hydrophilic interaction chromatography (HILIC)-type sorbents were newly developed for the solid-phase extraction (SPE) of polar compounds. Two methacrylate-base resins with different cross-linking monomers and pore properties were synthesized, and three polyethyleneimines (PEIs) with different molecular weights were modified onto each base resin. In both cases, PEIs with a molecular weight of 10,000 (PEI-10,000) exhibited the highest adsorption properties for polar compounds (uracil, uridine, adenosine, cytidine, and guanosine). To control the water-enriched layer at the surface of the PEI-10,000-modified sorbents, the additive amount of PEI-10,000 in the modified reaction was also optimized. When 10 times the amount of PEI-10,000 to each base resin was added, an improvement in adsorption property was observed. Moreover, the use of a nonaqueous sample solution (100% acetonitrile) during the sample loading process drastically improved adsorption, especially for uracil (about 80%) and adenosine (100%). These results indicate that the formation of a strong water-enriched layer at the surface of sorbents with an effective expression of hydrophilic interaction was an important factor in the adsorption properties of polar compounds in HILIC mode-SPE.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('173','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_173\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Hydrophilic interaction chromatography (HILIC)-type sorbents were newly developed for the solid-phase extraction (SPE) of polar compounds. Two methacrylate-base resins with different cross-linking monomers and pore properties were synthesized, and three polyethyleneimines (PEIs) with different molecular weights were modified onto each base resin. In both cases, PEIs with a molecular weight of 10,000 (PEI-10,000) exhibited the highest adsorption properties for polar compounds (uracil, uridine, adenosine, cytidine, and guanosine). To control the water-enriched layer at the surface of the PEI-10,000-modified sorbents, the additive amount of PEI-10,000 in the modified reaction was also optimized. When 10 times the amount of PEI-10,000 to each base resin was added, an improvement in adsorption property was observed. Moreover, the use of a nonaqueous sample solution (100% acetonitrile) during the sample loading process drastically improved adsorption, especially for uracil (about 80%) and adenosine (100%). These results indicate that the formation of a strong water-enriched layer at the surface of sorbents with an effective expression of hydrophilic interaction was an important factor in the adsorption properties of polar compounds in HILIC mode-SPE.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('173','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_173\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1007\/s44211-022-00250-z\" title=\"Follow DOI:10.1007\/s44211-022-00250-z\" target=\"_blank\">doi:10.1007\/s44211-022-00250-z<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('173','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> \u7530\u4e2d, \u674f\u5948;  \u843d\u5408, \u967d\u9999;  \u718a\u7530, \u82f1\u5cf0;  \u698e\u672c, \u525b\u53f8;  \u6885\u6751, \u77e5\u4e5f<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('177','tp_links')\" style=\"cursor:pointer;\">\u30a2\u30df\u30ce\u9178\u306e\u30da\u30f3\u30bf\u30d5\u30eb\u30aa\u30ed\u30d9\u30f3\u30b8\u30eb\u8a98\u5c0e\u4f53\u306eGC\/EI-MS\u306b\u3088\u308b\u89e3\u6790<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">\u5206\u6790\u5316\u5b66, <\/span><span class=\"tp_pub_additional_volume\">vol. 72, <\/span><span class=\"tp_pub_additional_number\">no. 10.11, <\/span><span class=\"tp_pub_additional_pages\">pp. 407-416, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_resource_link\"><a id=\"tp_links_sh_177\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('177','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_177\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('177','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_177\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{\u7530\u4e2d\u674f\u59482023,<br \/>\r\ntitle = {\u30a2\u30df\u30ce\u9178\u306e\u30da\u30f3\u30bf\u30d5\u30eb\u30aa\u30ed\u30d9\u30f3\u30b8\u30eb\u8a98\u5c0e\u4f53\u306eGC\/EI-MS\u306b\u3088\u308b\u89e3\u6790},<br \/>\r\nauthor = {\u7530\u4e2d,\u674f\u5948 and \u843d\u5408,\u967d\u9999 and \u718a\u7530,\u82f1\u5cf0 and \u698e\u672c,\u525b\u53f8 and \u6885\u6751,\u77e5\u4e5f},<br \/>\r\ndoi = {10.2116\/bunsekikagaku.72.407},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-01-01},<br \/>\r\nurldate = {2023-01-01},<br \/>\r\njournal = {\u5206\u6790\u5316\u5b66},<br \/>\r\nvolume = {72},<br \/>\r\nnumber = {10.11},<br \/>\r\npages = {407-416},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('177','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_177\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.2116\/bunsekikagaku.72.407\" title=\"Follow DOI:10.2116\/bunsekikagaku.72.407\" target=\"_blank\">doi:10.2116\/bunsekikagaku.72.407<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('177','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Uchida, Masao;  Mantoku, Kanako;  Kumata, Hidetoshi;  Kaneyasu, Naoki;  Handa, Daishi;  Arakaki, Takemitsu;  Kobayashi, Toshiyuki;  Hatakeyama, Shiro;  Shibata, Yasuyuki;  Kawamura, Kimitaka<\/p><p class=\"tp_pub_title\">Source apportionment of black carbon aerosols by isotopes (14C and 13C) and Bayesian modeling from two remote islands in east Asian outflow region <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, <\/span><span class=\"tp_pub_additional_volume\">vol. 538, <\/span><span class=\"tp_pub_additional_pages\">pp. 64\u201374, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_178\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('178','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_178\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{uchida2023source,<br \/>\r\ntitle = {Source apportionment of black carbon aerosols by isotopes (14C and 13C) and Bayesian modeling from two remote islands in east Asian outflow region},<br \/>\r\nauthor = {Masao Uchida and Kanako Mantoku and Hidetoshi Kumata and Naoki Kaneyasu and Daishi Handa and Takemitsu Arakaki and Toshiyuki Kobayashi and Shiro Hatakeyama and Yasuyuki Shibata and Kimitaka Kawamura},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-01-01},<br \/>\r\njournal = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},<br \/>\r\nvolume = {538},<br \/>\r\npages = {64\u201374},<br \/>\r\npublisher = {Elsevier},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('178','tp_bibtex')\">Close<\/a><\/p><\/div><\/div><\/div><\/div><\/div>\n\n\n<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\"><a name=\"tppubs\" id=\"tppubs\"><\/a><\/form><div class=\"teachpress_publication_list\"><h3 class=\"tp_h3\" id=\"tp_h3_2022\">2022<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Shoji, Atsushi;  Nakajima, Miyu;  Morioka, Kazuhiro;  Fujimori, Eiji;  Umemura, Tomonari;  Yanagida, Akio;  Hemmi, Akihide;  Uchiyama, Katsumi;  Nakajima, Hizuru<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('176','tp_links')\" style=\"cursor:pointer;\">Development of a surface plasmon resonance sensor using an optical fiber prepared by electroless displacement gold plating and its application to immunoassay<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Talanta, <\/span><span class=\"tp_pub_additional_volume\">vol. 240, <\/span><span class=\"tp_pub_additional_pages\">pp. 123162, <\/span><span class=\"tp_pub_additional_year\">2022<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1873-3573<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_176\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('176','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_176\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('176','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_176\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('176','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_176\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{pmid34996015,<br \/>\r\ntitle = {Development of a surface plasmon resonance sensor using an optical fiber prepared by electroless displacement gold plating and its application to immunoassay},<br \/>\r\nauthor = {Atsushi Shoji and Miyu Nakajima and Kazuhiro Morioka and Eiji Fujimori and Tomonari Umemura and Akio Yanagida and Akihide Hemmi and Katsumi Uchiyama and Hizuru Nakajima},<br \/>\r\ndoi = {10.1016\/j.talanta.2021.123162},<br \/>\r\nissn = {1873-3573},<br \/>\r\nyear  = {2022},<br \/>\r\ndate = {2022-04-01},<br \/>\r\njournal = {Talanta},<br \/>\r\nvolume = {240},<br \/>\r\npages = {123162},<br \/>\r\nabstract = {A simple and low-cost method of fabricating an optical fiber for a surface plasmon resonance (SPR) sensor was proposed. The method is based on the electroless nickel plating and subsequent displacement gold plating of the core of the optical fiber. The thickness of the nickel and gold thin films deposited on the core of the optical fiber could be controlled by measuring the reflected light intensity from the tip of the optical fiber during the plating processes. The sensitivity and resolution of the SPR sensor with the fabricated optical fiber in the refractive index range from 1.333 to 1.348 were 1324.3 nm\/RIU and 7.6\u00a0\u00d7\u00a010 RIU, respectively. The developed SPR sensor was successfully used in the determination of immunoglobulin A (IgA) in human saliva. The IgA quantification results obtained by the SPR sensor were in excellent agreement with those obtained by conventional enzyme-linked immunosorbent assay using a 96-well microtiter plate.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('176','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_176\" style=\"display:none;\"><div class=\"tp_abstract_entry\">A simple and low-cost method of fabricating an optical fiber for a surface plasmon resonance (SPR) sensor was proposed. The method is based on the electroless nickel plating and subsequent displacement gold plating of the core of the optical fiber. The thickness of the nickel and gold thin films deposited on the core of the optical fiber could be controlled by measuring the reflected light intensity from the tip of the optical fiber during the plating processes. The sensitivity and resolution of the SPR sensor with the fabricated optical fiber in the refractive index range from 1.333 to 1.348 were 1324.3 nm\/RIU and 7.6\u00a0\u00d7\u00a010 RIU, respectively. The developed SPR sensor was successfully used in the determination of immunoglobulin A (IgA) in human saliva. The IgA quantification results obtained by the SPR sensor were in excellent agreement with those obtained by conventional enzyme-linked immunosorbent assay using a 96-well microtiter plate.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('176','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_176\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1016\/j.talanta.2021.123162\" title=\"Follow DOI:10.1016\/j.talanta.2021.123162\" target=\"_blank\">doi:10.1016\/j.talanta.2021.123162<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('176','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Miki, Yuta;  Murakami, Hiroya;  Iida, Keisuke;  Umemura, Tomonari;  Esaka, Yukihiro;  Inoue, Yoshinori;  Teshima, Norio<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('175','tp_links')\" style=\"cursor:pointer;\">Preparation and evaluation of molding-type solid-phase extraction media binding with commercially available adhesives<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Anal Sci, <\/span><span class=\"tp_pub_additional_volume\">vol. 38, <\/span><span class=\"tp_pub_additional_number\">no. 2, <\/span><span class=\"tp_pub_additional_pages\">pp. 307\u2013315, <\/span><span class=\"tp_pub_additional_year\">2022<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1348-2246<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_175\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('175','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_175\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('175','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_175\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('175','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_175\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{pmid35314976,<br \/>\r\ntitle = {Preparation and evaluation of molding-type solid-phase extraction media binding with commercially available adhesives},<br \/>\r\nauthor = {Yuta Miki and Hiroya Murakami and Keisuke Iida and Tomonari Umemura and Yukihiro Esaka and Yoshinori Inoue and Norio Teshima},<br \/>\r\ndoi = {10.2116\/analsci.21P265},<br \/>\r\nissn = {1348-2246},<br \/>\r\nyear  = {2022},<br \/>\r\ndate = {2022-02-01},<br \/>\r\njournal = {Anal Sci},<br \/>\r\nvolume = {38},<br \/>\r\nnumber = {2},<br \/>\r\npages = {307--315},<br \/>\r\nabstract = {A fabrication method of molding-type solid-phase extraction media (M-SPEM) bound with commercially available adhesive is presented. Six pieces of M-SPEM were prepared by heating each kneaded product of a particulate sorbent and an adhesive inserted into a six-hole cylindrical mold for hardening under an open system and normal pressure. The particulate sorbent contained in M-SPEM was divinylbenzene-based reversed-phase mode solid-phase extractants that we have reported. An examination of several adhesives showed that the moldability of M-SPEM depended on the composition and properties of the adhesive. The optimized procedure can be used to prepare an M-SPEM containing an 85 wt% particulate sorbent (particulate sorbent\/adhesive, 100\u00a0mg\/17\u00a0mg; particle diameter, 90-150\u00a0\u00b5m), and the M-SPEM has a specific surface area of about 500\u00a0m\/g. The established procedure in this study can bind particulate sorbents together, which showed almost no reductions in the adsorption property and liquid permeability compared with those of the particulate sorbent.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('175','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_175\" style=\"display:none;\"><div class=\"tp_abstract_entry\">A fabrication method of molding-type solid-phase extraction media (M-SPEM) bound with commercially available adhesive is presented. Six pieces of M-SPEM were prepared by heating each kneaded product of a particulate sorbent and an adhesive inserted into a six-hole cylindrical mold for hardening under an open system and normal pressure. The particulate sorbent contained in M-SPEM was divinylbenzene-based reversed-phase mode solid-phase extractants that we have reported. An examination of several adhesives showed that the moldability of M-SPEM depended on the composition and properties of the adhesive. The optimized procedure can be used to prepare an M-SPEM containing an 85 wt% particulate sorbent (particulate sorbent\/adhesive, 100\u00a0mg\/17\u00a0mg; particle diameter, 90-150\u00a0\u00b5m), and the M-SPEM has a specific surface area of about 500\u00a0m\/g. The established procedure in this study can bind particulate sorbents together, which showed almost no reductions in the adsorption property and liquid permeability compared with those of the particulate sorbent.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('175','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_175\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.2116\/analsci.21P265\" title=\"Follow DOI:10.2116\/analsci.21P265\" target=\"_blank\">doi:10.2116\/analsci.21P265<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('175','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Ishii, Ryo;  Morioka, Kazuhiro;  Mizumoto, Takuya;  Yamasaki, Natsumi;  Hemmi, Akihide;  Shoji, Atsushi;  Murakami, Hiroya;  Teshima, Norio;  Umemura, Tomonari;  Uchiyama, Katsumi;  Nakajima, Hizuru<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('163','tp_links')\" style=\"cursor:pointer;\">Development of Portable Fluorescence Microplate Reader Equipped with Indium Tin Oxide Glass Heater for Loop-mediated Isothermal Amplification<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_journal\">Sensors and Materials, <\/span><span class=\"tp_pub_additional_volume\">vol. 34, <\/span><span class=\"tp_pub_additional_pages\">pp. 1, <\/span><span class=\"tp_pub_additional_year\">2022<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_resource_link\"><a id=\"tp_links_sh_163\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('163','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_163\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('163','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_163\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{article,<br \/>\r\ntitle = {Development of Portable Fluorescence Microplate Reader Equipped with Indium Tin Oxide Glass Heater for Loop-mediated Isothermal Amplification},<br \/>\r\nauthor = {Ryo Ishii and Kazuhiro Morioka and Takuya Mizumoto and Natsumi Yamasaki and Akihide Hemmi and Atsushi Shoji and Hiroya Murakami and Norio Teshima and Tomonari Umemura and Katsumi Uchiyama and Hizuru Nakajima},<br \/>\r\ndoi = {10.18494\/SAM.2022.3618},<br \/>\r\nyear  = {2022},<br \/>\r\ndate = {2022-01-01},<br \/>\r\njournal = {Sensors and Materials},<br \/>\r\nvolume = {34},<br \/>\r\npages = {1},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('163','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_163\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.18494\/SAM.2022.3618\" title=\"Follow DOI:10.18494\/SAM.2022.3618\" target=\"_blank\">doi:10.18494\/SAM.2022.3618<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('163','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><\/div><\/div>\n\n\n<div>You need to add a widget, row, or prebuilt layout before you&#8217;ll see anything here. \ud83d\ude42<\/div>","protected":false},"excerpt":{"rendered":"<p>\u4eba\u306e\u5fc3\u3068\u5065\u5eb7\u3092\u5b88\u308b\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u5c55\u958b\u3057\u307e\u3059 \u4eba\u306e\u5b89\u5fc3\u30fb\u5b89\u5168\u3092\u652f\u3048\u308b\u8a3a\u65ad\u85ac\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u5c55\u958b\u3057\u307e\u3059 &nbsp; 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