Akihiko Yamagishi

Tokyo University of Pharmacy and Life Science, Professor., Ph.D.

Office

• Tokyo University of Pharmacy and Life Science
• Department of Molecular Biology
• 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
• Phone: +81-426-76-7139
• Fax: +81-426-76-7145
• E-mail: yamagish@ls.toyaku.ac.jp
  (When you send e-mail by PC software, please add "ls.toyaku.ac.jp" after "@")

Early evolution of life

• Searching hyper-thermophiles form marine hydrothermal area
• Analyzing genes and proteins of hyperthermophiles
• Making ancestral enzymes
• Searching microbes at high atmosphere

Evolutionary process forming eukaryotic cells

• Analyzing cell structure of Thermoplasma
• Analyzing ether-lipid biosynthetic pathway
• We have found thermoplasma related PCR clones in termite gut

Protein engineering: thermal stability of proteins

• Analyzing thermal stability of proteins of thermophilic microbes
• Molecular dynamics calculations by using MD engines
• Trying to make the way of designing proteins at will

Evolutionary molecular engineering

• To make component for nano technology
• To make proteins thermo stable
• Low temperature adaptation of thermophilic enzymes
• Designing new substrate specificity of enzymes
• To develop genetic engineering system for thermophiles