講 演 会
日時 3月23日(木)11:10-12:40
場所:4301講義室


講師:Dr. Tobias P. Dick
German Cancer Research Center
Division Head

 

“Mechanisms of redox signaling”

 

要旨:Redox signaling is a process by which endogenous oxidants, derived from metabolism,
reversibly modify particular thiols on particular proteins to change their functional behavior in
an adaptive manner. However, the molecular mechanisms of redox signaling remain largely
unknown. In particular, specificity and efficiency of redox signaling remain largely
unexplained. The now emerging solution to this conundrum is that redox signaling is mediated
and channeled by protein-to-protein redox relay chains. There is growing evidence that H2O2
signals are relayed through thiol peroxidases to neighboring proteins within supramolecular
assemblies. Evidence now suggests that so far we may have just glimpsed the ‘tip of the
iceberg’, in that redox relay chains are ubiquitous and also operate for reactive nitrogen and
sulfur species.

 

参考文献
Morgan B, et al Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes. Nature Chemical Biology
12: 437-443 (2016)
Fujikawa Y, et al Mouse redox histology using genetically encoded probes. Science Signaling 9: rs1 (2016)
Peralta D, et al A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nature Chemical
Biology 11:156-163 (2015)
Sobotta MC, et al Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nature Chemical Biology 11:64-70
(2015)
Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TPMultiple glutathione disulfide removal pathways mediate
cytosolic redox homeostasis. Nature Chemical Biology 9:119-125 (2013)

 

主催: 分子生物化学研究室
共催: 私立大学戦略的研究基盤形成支援事業「健康で豊かな生活を実現するスマートタンパク質工学戦略的研究拠点」
連絡先: 分子生物化学研究室 藤川 雄太(4331)